By Sarah Bradley | Jun. 15, 2021Medically reviewed by Laura K. Grubb, MD, MPH

Use of Topamax isn’t advised during any part of pregnancy—but especially during the first trimester due to the instances of birth defects involving the facial area, according to Kecia Gaither, MD, OB-GYN and maternal fetal medicine specialist, director of perinatal services at NYC Health + Hospitals/Lincoln. “Topamax may also increase the incidence of hemorrhagic disease in the newborn by depleting fetal vitamin K stores,” Dr. Gaither adds. Vitamin K is responsible for forming blood clots and preventing excessive bleeding; ongoing deficiency in infants can be life-threatening.

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