By Wendy Wisner, Jan 6, 2026
Estradiol vaginal cream works by delivering estrogen hormones directly to the vaginal mucosa, explains Kecia Gaither, MD, double board-certified in OB-GYN and maternal fetal medicine and director of perinatal and maternal fetal medicine at NYC Health + Hospital. “The result is improved vaginal moisture, thickness, blood flow, and elasticity, relieving symptoms of dryness, itching, burning, and pain during intercourse,” she explains.
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